Biological pathway for atmospheric particles on health

What is oxidative stress?

Oxidative stress is an internal biological imbalance that can lead to health problems. Oxidative stress is linked to an imbalance between unstable molecules called free radicals and antioxidants, which are molecules that neutralize these free radicals. When free radicals outnumber antioxidants, oxidative stress can result, which can have serious health consequences.
Exposure to atmospheric particles could responsible for a part of this oxidative stress. Therefore, using the data from the SEPAGES cohort, we were able to study the role of oxidative potential of fine particles (PM2.5) on oxidative stress.

How to measure oxidative stress?

Three oxidative stress biomarkers were measured in urine collected during pregnancy. The biomarkers measured provided information on the oxidation of certain cell components: lipids (fats) and DNA. In other words, these biomarkers can tell us whether these cellular components have been damaged.

Main results

This study suggests that exposure to the oxidative potential of fine particles (PM2.5) may impact a biomarker linked to DNA oxidation.

What’s next ?

These results suggest that exposure to particulate matter causes oxidative stress to DNA, i.e. DNA damage. Future studies could investigate the effects of DNA damage on various health parameters, including those related to fetal growth.