Effects of phthalates on placental health

Phthalates, what are they?
Phthalates are chemicals ubiquitous in our environment, found in food packaging, cosmetics, and even some toys. These chemicals can interfere with the normal development of the placenta, a crucial organ that nourishes the fetus throughout pregnancy. Phthalates were measured in urine samples collected during pregnancy (42 samples).
Main results
Our results indicate that phthalates can decrease placental weight and impair its function, particularly in male fetuses. This suggests that exposure to phthalates during pregnancy could have more pronounced effects depending on the baby’s sex.
Why does this matter?
The placenta plays a critical role in delivering oxygen and nutrients to the fetus while removing waste. If the placenta does not function properly, it can jeopardize the baby's health. Our findings indicate that phthalates, which are prevalent in our surroundings, could pose risks to fetal development.
Innovative study approach
This study is among the first to use repeated urine samples to get a clear picture of phthalate exposure during pregnancy, allowing for a better understanding of their potentially harmful effects. Monitoring and regulating exposure to phthalates is crucial to protect future generations. Informing the public and policymakers about these risks is an important step towards preventing the negative impacts of chemicals on reproductive health.
To go further: Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, Cathrine Thomsen, Amrit Kaur Sakhi, Azemira Sabaredzovic, Sam Bayat, Anne Couturier-Tarrade, Rémy Slama, Claire Philippat. “Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy”. Human Reproduction Open, April 2024
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